Quality products?make an important contribution to long-term revenue and profitability. China cas 6112-76-1 manufacturer wholesale 6-Mercaptopurine monohydrate at affordable price

1.What is the 6-Mercaptopurine monohydrate ?

Mercaptopurine (Purinethol) is an analogue of hypoxanthine and was one of the first agents shown to be active against acute leukemias. It is now used as part of maintenance therapy in acute lymphoblastic leukemia. Mercaptopurine must be activated to a nucleotide by the enzyme HGPRTase. This metabolite is capable of inhibiting the synthesis of the normal purines adenine and guanine at the initial aminotransferase step and inhibiting the conversion of inosinic acid to the nucleotides adenylate and guanylate at several steps. Some mercaptopurine is also incorporated into DNA in the form of thioguanine. The relative significance of these mechanisms to the antitumor action of mercaptopurine is not clear. Resistance to mercaptopurine may be a result of decreased drug activation by HGPRTase or increased inactivation by alkaline phosphatase. The plasma half-life of an intravenous bolus injection of mercaptopurine is 21 minutes in children and 47 minutes in adults. After oral administration, peak plasma levels are attained within 2 hours. The drug is 20% bound to plasma proteins and does not enter the CSF. Xanthine oxidase is the primary enzyme involved in the metabolic inactivation of mercaptopurine. Mercaptopurine is used in the maintenance therapy of acute lymphoblastic leukemia. It also displays activity against acute and chronic myelogenous leukemias. The major toxicities of mercaptopurine are myelosuppression, nausea, vomiting, and hepatic toxicity.

antihypertensive, ACE inhibitor

2.What is the CAS number for 6-Mercaptopurine monohydrate ?

The CAS number of 6-Mercaptopurine monohydrate is 6112-76-1.

More information of 6-Mercaptopurine monohydrate 6112-76-1 are:

3.What are another words for 6-Mercaptopurine monohydrate ?

Synonyms?for?6-Mercaptopurine monohydrate 6112-76-1:6H-Purine-6-thione,1,7-dihydro-, monohydrate (9CI);Purine-6-thiol, monohydrate (8CI);Mercaptopurine;

4.What is the molecular formula of 6-Mercaptopurine monohydrate?

The chemical formula of ?6-Mercaptopurine monohydrate is?C5H4N4S.H2O which containing 5 Carbon atoms,6 Hydrogen atoms,4 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of??6-Mercaptopurine monohydrate?is 170.195.

5.What is 6-Mercaptopurine monohydrate (6112-76-1) used for?

6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion. It is rapidly converted to 6-mercaptopurine ribonucleoside-5''-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limiting enzyme in purine synthesis. It also inhibits the conversion of IMP to adenylosuccinic acid and xanthylic acid and blocks AMP formation in vitro. 6-MP (30 mg/kg) inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice. It also decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset. Formulations containing mercaptopurine have been used for maintenance therapy in patients with acute lymphoblastic leukemia.

InChI:InChI=1/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)/p-1

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6.Buy 6-Mercaptopurine monohydrate with the best price .

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